Health Articles

Sulphoraphane and brocoli

20 June 2023

Unlocking the Health Benefits of Sulforaphane

In the realm of women’s health, certain compounds hold immense potential for promoting human health. One such remarkable molecule that has been getting attention in recent years is sulforaphane. This compound, found in delicious veggies like broccoli, cauliflower, and kale, is like a superhero for your body. It's been making headlines for all the right reasons, and I’m here to tell you all about it.

In this article, we will delve into sulforaphane, its actions and the exciting possibilities it offers for enhancing your well-being.


What is Sulforaphane?

Sulforaphane is a naturally occurring compound belonging to the family of isothiocyanates. It is derived from a precursor called glucoraphanin. Which is found in high concentrations in cruciferous vegetables. When these vegetables are chopped, chewed, or otherwise damaged, an enzyme called myrosinase converts glucoraphanin into sulforaphane.

Furthermore, it's worth noting that our gut bacteria can also produce myrosinase. Which enables the conversion of glucoraphanin to sulforaphane. However, it's important to acknowledge that the efficiency of this conversion can vary significantly from person to person and relies on the overall health of their gut flora.


Sulforaphane has 5 main health benefits:

Let's dive into each benefit: 

      Powerful Antioxidant and Detoxifier:

One of the primary reasons sulforaphane has gained significant attention is its powerful antioxidant properties. Antioxidants play a crucial role in neutralizing harmful free radicals in the body. They reduce oxidative stress and mitigate the risk of chronic diseases. Sulforaphane has been shown to stimulate the production of enzymes that assist in detoxification processes within our cells. In turn, enhancing the body's natural defense systems against oxidative damage.

Particularly important with hormones with things like endometriosis, perimenopause and menopause. Where optimally functioning detoxification pathways aid in removing excess hormones from the body.

       Potential Cancer-Fighting Abilities:

Sulforaphane's potential as a cancer-fighting compound has sparked considerable interest among researchers. Studies have demonstrated its ability to inhibit the growth of cancer cells and induce their apoptosis (programmed cell death). By activating protective pathways and promoting detoxification, sulforaphane exhibits chemo-preventive properties, making it a valuable ally in the fight against cancer.


Inflammation is a common factor in various chronic diseases. Sulforaphane exhibits anti-inflammatory effects by inhibiting the activation of inflammatory pathways. By reducing inflammation, sulforaphane may contribute to the prevention and management of some conditions. Including cardiovascular disease, arthritis, and certain gastrointestinal disorders. It can also aid in inflammatory driven conditions like endometriosis and adenomyosis.


      Cardiovascular Health:

Maintaining a healthy cardiovascular system is vital for overall well-being. Sulforaphane has been associated with several cardiovascular benefits. It helps lower blood pressure, reduces inflammation and improves lipid profiles by increasing HDL (good) cholesterol. It may inhibit the formation of plaque in the arteries. These effects suggest that sulforaphane may play a role in preventing heart disease and reducing the risk of cardiovascular events.


      Brain and Cognitive Protection:

The potential neuroprotective properties of sulforaphane have garnered attention in the field of neuroscience. Studies have suggested that sulforaphane may help protect against neurodegenerative conditions like Alzheimer's and Parkinson's diseases. It exerts its effects by reducing oxidative stress, suppressing inflammation, and promoting the activation of various protective pathways in the brain.


How to get more Sulforaphane in your diet:

Is it just as easy as eating more cruciferous vegetables? Unfortunately, not, here’s why.

There are two primary methods for increasing sulforaphane levels: consuming broccoli sprouts and taking supplements. However, the question arises: can’t I just include more cruciferous vegetables such as broccoli or cabbage into my diet? Personally, I strongly advocate for obtaining nutrients from food whenever possible, however with sulforaphane, the situation becomes a little more complex.


One challenge with relying solely on cruciferous vegetables is the presence of epithiospecifier protein (ESP) in these plants. ESP significantly hampers the activity of myrosinase, the enzyme responsible for converting sulforaphane precursors in cruciferous vegetables like broccoli into actual sulforaphane. This means that consuming cruciferous vegetables alone is an unreliable source of sulforaphane, unfortunately.


Another drawback to solely relying on cruciferous vegetables is that cooking has been found to destroy myrosinase. Therefore, cooking reduces the potential for sulforaphane production.


The good news is you can increase sulforaphane by consuming Broccoli Sprouts. Broccoli sprouts contain glucosinolates, the sulforaphane precursors. Then the myrosinase, which can be produced by chewing, cutting or blending (in a smoothie) or sometimes by the gut bacteria converts these glycosinalates to sulforaphane and eurin, which is another beneficial isothiocyanate compound.  Consuming broccoli sprouts often has a higher bioavailability than with supplements.


Sulforaphane, the potent compound found abundantly in cruciferous vegetables, is proving to be a key nutrient when it comes to promoting health and preventing diseases. Its remarkable antioxidant, anti-inflammatory, and detoxifying properties have made it the subject of intense scientific research.

I particularly love using it in the clinic when treating patients with gut health, inflammation eczema, ADHD, autism and hormone detoxification.

To find out if you would benefit from sulforaphane, ask in your naturopath appointments with me or book a consultation to go over your health history and work out a treatment plan.